It is true that Yulia Proskuryakova is pregnant. Julia Proskuryakova first spoke about the long-awaited pregnancy. Maxim Galkin and Alla Pugacheva revealed the intrigue with the pregnancy of Yulia Proskuryakova
One tablet contains active substances: 2,4-dichlorobenzyl alcohol - 1.2 mg, amylmetacresol - 0.6 mg.
Excipients:
lozenges: tartaric acid 26 mg, levomenthol (natural) 4.49 mg, peppermint leaf oil 0.48 mg, common anise seed oil 2.3 mg, crimson dye [Ponceau 4R] (Edicol CI 16255, E 124) 0.32 mg , dye azorubin (Edicol CI 14720, E 122) 0.05 mg, sugar syrup (sucrose, water), liquid dextrose [dextrose, oligo- and polysaccharides] (liquid glucose) to obtain a tablet weighing 2.6 g.
lozenges [honey-lemon]: tartaric acid 26 mg, honey 125.6 mg, peppermint leaf oil 0.62 mg, lemon oil (terpene-free) 2.03 mg, quinoline yellow dye (E 104) 0.099 mg, sugar syrup (sucrose, water), dextrose liquid [dextrose, oligo- and polysaccharides] (liquid glucose) to obtain a tablet weighing 2.6 g.
Description
Lozenges:
red round tablets with a predominant anise odor with the image of the letter S on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.
Lozenges [honey-lemon]:
yellow round tablets with the image of the letter S on both sides of the tablet. A white coating, uneven coloring, the presence of air bubbles in the caramel mass and a slight unevenness of the edges are allowed.
pharmachologic effect
2,4-dichlorobenzyl alcohol and amylmetacresol are antiseptics and have antibacterial, antifungal and antiviral properties. Amylmetacresol and 2,4-dichlorobenzyl alcohol also reversibly block pre-polarization-induced ion channels, similar to the action of local anesthetics. The combination of these active substances in one preparation leads to a synergistic antibacterial effect and a decrease in the combined dose in Strepsils tablets.
The antibacterial and antifungal activity of Strepsils has been demonstrated in in vitro and in vivo studies. Antiviral activity against enveloped viruses has also been demonstrated in vitro after contact with Strepsils tablets for 1 minute. The long history of the global use of Strepsils tablets has not demonstrated a decrease in their activity against various pathogenic agents, which suggests that resistance has not developed.
In clinical studies, the analgesic effect of Strepsils was demonstrated in the form of a decrease in the soreness of the pharynx, relief of pain when swallowing, lasting from 5 minutes to 2 hours. Significantly greater symptom relief was observed with this drug for three days compared with non-drug treatment.
Strepsils with Honey and Lemon contains flavorings and honey that provide sensory stimulation while the tablet base acts on the sore throat.
Pharmacokinetics
Oral bioavailability studies conducted for Strepsils demonstrated a rapid release of 2,4-dichlorobenzyl alcohol and amylmethacresol in saliva, peaking at 3-4 minutes of tablet resorption. A doubling of saliva volume was observed within one minute and levels were maintained above baseline while the tablet was dissolving for about 6 minutes.
Measurable amounts of active substances were expectorated up to 20-30 minutes after dosing; the pure recovery of active substances indicates a long-term residue of them both on the oral mucosa and on the pharyngeal mucosa.
Scintigraphic studies of Strepsils with sugar demonstrated the gradual dissolution of the tablet with the deposition of dissolving substances on the oral and pharyngeal mucosa from 2 minutes after the start of tablet resorption and within 2 hours after resorption, providing long-term relief of irritation in the throat.
When administered orally, the acute toxicity of 2,4-dichlorobenzyl alcohol and amylmethacresol is negligible with a wide margin of safety, and toxicological studies of n^n^pvanide indicate that little kidney damage occurs at four times the standard dose.
In chronic toxicity studies in rats, an increase in kidney and liver weight was found after daily oral doses of 200 and 400 mg/kg of 2,4-dichlorobenzyl alcohol (far in excess of the daily dose). In addition, depending on the dose, damage to the gastric mucosa in the form of ulcerative erosions and necrosis was observed along with hyperplasia and hyperkeratosis of the epithelium.
Conducted in vitro and in vivo studies of the genotoxicity of amylmethacresol and 2,4-dichlorobenzyl alcohol did not reveal any potential genotoxic risk when used at recommended doses. Genotoxicity data and long-term clinical use have not shown a risk of carcinogenicity. An embryotoxicity study in rabbits and prospective safety studies in humans provide no evidence of possible teratogenic effects. Studies in rabbits using a dose 50 times higher than the standard dose did not reveal the effect of Strepsils on the course of pregnancy, fetal development, or the detection of malformations. There are no data available on effects on fertility or development after birth.
Indications for use
To alleviate the symptoms of infectious and inflammatory diseases of the oral cavity and pharynx.
Contraindications
Hypersensitivity to the components of the drug; childhood(up to 6 years).
Pregnancy and lactation
The safety of the use of Strepsils lozenges (honey-lemon) during pregnancy and lactation has not been established, but the drug is not considered dangerous.
Dosage and administration
For oral use.
It is used in adults and children over 6 years of age.
It is necessary to slowly dissolve in the mouth 1 tablet every 2-3 hours, but not more than 12 tablets within 24 hours.
The drug is not intended for children under 6 years of age.
Use by elderly patients: no dosage reduction is required.
In case of missing the next dose of the drug, it is recommended to take the dose in accordance with the prescribed dosing regimen, without doubling the amount of the drug.
Side effect
Adverse reactions that may occur with short-term use of the drug are listed by frequency of occurrence in the following order:
Very common: >1/10
Common: > 1/100 to<1/10
Uncommon: > 1/1,000 to<1/100
Rare: > 1/10,000 to<1/1, 000
Rarely:<1/10, 000
In each class of organs and systems, undesirable effects are presented in order of decreasing frequency.
With prolonged use of the drug, additional adverse reactions may occur.
From the side of the immune system
Hypersensitivity
From the side of the respiratory system, chest and mediastinum - Edema of the pharynx
From the gastrointestinal tract
Discomfort in the mouth (burning sensation in the mouth)
There may also appear: a burning sensation or tingling in the throat, a sensation of tingling of the oral mucosa, swelling of the oral mucosa, tongue pain, dyspepsia, nausea.
On the part of the skin and subcutaneous tissues - Rash.
In the event of unusual reactions, you should consult your doctor about the advisability of further use of the drug.
Overdose
Symptoms: Overdose is unlikely. A possible overdose can lead to discomfort from the gastrointestinal tract: nausea. Treatment: symptomatic under medical supervision.
Throat. And if the treatment of the disease should take place in a complex way, then it can be facilitated by dissolving lollipops or.
Composition, release form, packaging
The main active ingredients are amylmetacresol, 2,4 dichlorobenzyl alcohol.
Of the auxiliary components, we indicate:
- tartaric acid;
- peppermint oil;
- carmoisin;
- levomenthol;
- glucose solution;
- star anise oil;
- Ponceau 4R;
- sucrose solution.
The medicine is produced in the form of lozenges. They have a red color, embossing the letter "S" on both sides.
Lollipops are produced in cardboard packs containing blisters. Each blister contains 8 lozenges. In the package of such blisters there can be 1, 2, 3. Lozenges are produced in several types:
- original;
- with menthol;
- with vitamin C;
- with lemon, herbs, no sugar;
- with honey and lemon.
Release form
Manufacturer
Manufactured in the UK by Reckitt Benckiser Healthcare.
Indications
The drug is prescribed in the treatment of inflammatory diseases of the oral cavity, pharynx (acute, chronic). Successfully used in the treatment of:
- pharyngitis;
- laryngitis;
- periodontal disease;
- stomatitis;
- tonsillitis;
- aphthae.
The drug is used in ENT practice, dentistry for preventive purposes after surgery (tooth extraction, tonsillectomy). It prevents infection, development.
Contraindications
This medication has a list of contraindications for use:
- children's age up to 5 years;
- hypersensitivity to;
- individual intolerance to certain components of the drug.
Mechanism of action
The active substances that make up the drug destroy the bacterial cell membrane, have a dehydrating effect on the cells of microorganisms. Thus, there is a bacteriostatic, bactericidal effect.
Experts have established sensitivity to this drug of such bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Proteus spp., Streptococcus spp., Staphylococcus salivarius, Diplococcus pneumoniae Aerobacter spp., Staphylococcus pyogenes, aerobic / anaerobic microorganisms.
It has a fungicidal effect on fungi of the genus Candida. Therefore, lozenges are very effective in the treatment of diseases of the throat, pharynx, which are aggravated.
The presence of lozenges in the composition helps to soften the mucous membrane of the throat, pharynx due to increased salivation. An increase in the volume of saliva secreted during the resorption of the drug increases the antibacterial effect.
Instructions for use
The lozenge should be sucked until it is completely dissolved. You can not use more than 12 sucking tablets per day. The course of treatment is usually different. Its duration is influenced by such factors: the clinic of the disease, the severity of the disease.
Children over 6 years of age, adult patients, it is enough to take 1 lozenge every 2 to 3 hours.
How to quickly cure a sore throat:
Side effects
Among the side effects, manifestation deserves special attention. Occasionally, cases of changes in taste sensations were recorded. If you take the medication at a dose higher than recommended by a specialist, the following side effects may occur.
Singer and composer Igor Nikolaev and his wife Yulia Proskuryakova shared their emotions with reporters about the birth of their first baby. The couple hid their happiness for a long time, they were afraid to jinx it.
And although the topic is rather sensitive, but because of the constant calls and questions from reporters, Nikolaev and Proskuryakova decided to speak out. "Yes, Julia is pregnant!" - Igor confirmed the news about his wife's pregnancy. The married couple waited and begged God for this miracle for ten long years.
“All these years I had questions to God: why doesn’t He give us children, are Igor and I really not worthy of this miracle? After all, the Lord sees that we love each other, that we call the baby, we want him. So what’s the matter. But I never despaired - my intuition told me: there is a time for everything, "Proskuryakova told the publication" 7 Days ".
Nikolaev supported his wife. “Julia is right: everything in life happens in due time. After all, for many years I heard from my friends: “Old man, you must give birth to a child. You don’t understand how this will change you. "So Igor Krutoy told me when his daughter was born. And Sasha Kalyanov, who was nursing his grandson, called me every day:" It's such a thrill! "And recently at Max Galkin's birthday party, I saw how the children have grown since our last meeting with Alla. It seems like yesterday he was holding his goddaughter Lisa in his arms, and she has already become an impossible beauty blonde with huge blue eyes. Isn't this happiness? And now our time with Yulia has come, "the future father rejoices .
Julia found out about her pregnancy after a trip to Prague. “I discovered that something strange was happening to the body. I thought that the failure was due to long flights, jet lag, fatigue. In general, many reasons came to my mind, except for the most important one. For some reason, it always seemed to me that I will definitely feel when I get pregnant. But I didn’t feel it and didn’t guess. I went to the doctor to understand what was wrong with me, passed the tests, and a week later the doctor called: “Apparently, you have been in position for almost a month … "At that moment it seemed to me that the world around me froze and time stopped. - Nikolaev's wife recalls with a smile. - Finally, God heard our prayers and helped!"
To find out for sure, Proskuryakova bought five pregnancy tests at the pharmacy. “They all showed the same result: one bright strip, and the second is not very clear, some kind of pale. And then I was confused - what does this mean? Yes or no. I called my pregnant friend, and she reassured me: they say, so often it happens, and the second strip will also darken in a few hours ... These two hours I couldn’t think of anything else. And the stripes really evened out! - Julia said emotionally. - So, when Igor returned home, after dinner I showed him these five tests tested positive and said, "I think I'm pregnant. We will finally have a baby!" Igor was taken aback at first, and then hugged me: "Yulka, this is such a joy, such happiness! We have been waiting for this for so long, I can’t even believe that this has happened ... "
Yulia Proskuryakova and her husband Igor Nikolaev were one of the guests of honor at the spring festival in her house. The prima donna invited her closest and dearest friends to meet spring at a Greek party, the site reports.
As you know, at the spring festival, in addition to Nikolaev and Proskuryakova, Nikolai Baskov and many others.
As Juliana Ulitkina, a journalist from JoInfoMedia, managed to find out, the pictures from the Primadonna's party cause delight and admirers, but many also saw something curious in the form of singer Yulia Proskuryakova.
In one of the pictures with Alla Borisovna and Igor Nikolaev, Yulia covered her belly, which gave fans complete confidence that Yulia was pregnant.
Undoubtedly, fans of her work began to congratulate her and say nice words and compliments. Igor and Yulia's friends, Leonid Agutin and Alexander Serov, also joined the congratulations of Igor and Yulia.
“Cover your tummy! so cute)!”, “Well done! Congratulations to you!”, “What a beautiful you have become! It suits you!”, “Oh, what a beauty Yulechka!!! shines straight!!! and what is she covering her tummy ??? ”,“ she’s definitely pregnant, she’s never been like this before ”,“ Yulia is covering her tummy, will we congratulate you soon? ”, Fans write under the picture. (Orff. and Paragraph. of the author preserved, approx. Ed.).
Julia reacted ambiguously to such congratulations, answering fans ambiguously.
“Well, why do you all want to congratulate me, you can’t even touch your stomach or what? you start congratulating right away !!!" - the singer Yulia Proskuryakova wrote angrily, but at the same time she did not refute an interesting situation. (Orff. and Paragraph. Author saved, approx. Ed.).
Recall that Alla Borisovna Pugacheva with her appearance. Each time, fans note that the Primadonna is getting younger and more beautiful.
The reason for the rumors about the interesting position of Yulia was the photographs from the party of Alla Pugacheva, which the prima donna organized in honor of the arrival of spring. Netizens noticed that Proskuryakova and suggested that she was again preparing to give Igor Nikolaev a baby.
ON THIS TOPIC
"I'M NOT PREGNANT!!! NOT PREGNANT! I don't know how else to say it!!!" - wrote Proskuryakova, who, judging by the number of exclamation marks, is already losing her nerves from newspaper ducks.
It is noteworthy that Yulia quite often chooses loose outfits and keeps her hands on her stomach, so pen sharks regularly sin with premature announcements about the interesting position of the artist. “I don’t understand why all the time I can only be attributed to pregnancy! Comrade journalists do not start again deceiving readers, for 10 years you have attributed pregnancy to me every day, you can already stop doing this every time! NOT PREGNANT!!!” - the performer is indignant.
Commentators on the Internet Proskuryakova also called to order. "Well, you all want to congratulate me😂🙈 already and you can’t touch your stomach or what? You start congratulating me right away !!!" - complained the wife of Igor Nikolaev.
Recall that Igor Nikolaev and Yulia Proskuryakova got married in September 2010. Five years after this significant event, a daughter, Veronica, appeared in the family. The baby is already showing musical abilities. "We have a piano at home, on which dad plays, and daughter listens with joy. Then we put a small synthesizer on her lap, and she also tries to press the keys, repeat after dad. By the way, he composed several songs especially for Veronica, even the polka, which she really likes, the daughter even dances under her, "said in
