For what purposes is duphaston used during pregnancy. Duphaston during pregnancy and planning. Important questions about the drug. Why is duphaston needed during pregnancy

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Many women experience fertility problems or complications during pregnancy. Scientists have found that one of the factors provoking such deviations is a hormonal imbalance or lack of progesterone in a woman's body. To address these issues, as well as for the treatment and prevention of infertility, normalization of ovulation, doctors prescribe Duphaston during or before pregnancy.

Duphaston - instructions for use during pregnancy

The ovaries and adrenal glands in a woman's body perform one of the main roles - they produce the steroid hormone progesterone necessary for normal menstruation and successful conception. However, for various reasons, failures in the operation of these systems can occur, which will lead to a decrease in the level of the hormone in the woman's blood. In this case, for the successful bearing of the fetus, a medical drug Duphaston.

It is an analogue of the hormone progesterone of natural origin and is well accepted by the woman's body. The drug does not affect the functioning of the liver, but at the same time normalizes the tone of the smooth muscles of the uterus, without disturbing the menstrual cycle and ovulation. Such an effect on the body increases the chances of successfully bearing a baby: it prevents the risks of miscarriages or the freezing of the embryo. If a woman was diagnosed with increased uterine tone, then when taking these pills, in 85% of cases the child can be saved.

Composition and form of release

The medicine is sold in cardboard packs of 20 or 14 tablets. In addition to blisters, the box contains detailed instructions by application. The tablets themselves are small in shape, round with a division in the middle. On the back of the package there is information about the manufacturer, storage rules and composition. According to this, the basis of 1 tablet contains:

The action of the drug

When using the drug, the deficiency of natural hormones is compensated, due to which the percentage spontaneous miscarriage in the first weeks of pregnancy, the risks of developing fetal defects and abnormalities in the formation of the placental layer. Additional intake of synthetic progesterone in the body normalizes the hormonal background in a woman, provides a normal nutritional and oxygen balance for the fetus.

Absorption of active components into the blood occurs in the intestinal mucosa. The maximum concentration of substances is reached 1.5-2 hours after taking the medication. The half-life of the active ingredients occurs in the liver, and the remains of the drug are excreted by the kidneys along with urine. The duration of the period of their complete elimination is 70 hours.

Indications for use

The main indication for the appointment of Duphaston is a deficiency in the body of natural progesterone. Before starting treatment, a woman should be tested to confirm suspicions. According to instructions, it is advisable to take pills:

  • in the treatment of violations of the monthly cycle - delayed menstruation, normalization of the second stage of the cycle;
  • with severe premenstrual syndrome - pain in the abdomen, lower back, migraines;
  • if there is a threat of termination of early pregnancy;
  • with endometriosis;
  • for the treatment of infertility;
  • to preserve the fetus;
  • threatened or habitual abortion.

Duphaston in early pregnancy

During pregnancy, the drug will compensate for the lack of progesterone and take over its functions. The drug will support the activity of the corpus luteum during conception, relax the endometrium of the uterus, and have an immunosuppressive effect so that the body does not perceive the fertilized egg as a foreign body. If at the beginning of pregnancy there are signs of spontaneous abortion or other threat of miscarriage, taking a synthetic hormone is useful for maintaining the pregnancy.

At a later date

The duration of taking the tablets is determined by the doctor. As a rule, the medication is prescribed before conception and it is recommended to continue drinking until the 16-20th week of pregnancy. However, if there are certain indications, the doctor may prescribe Duphaston for later dates pregnancy. One of the reasons is the increased tone of the uterus, when there are risks premature birth. Anyway the drug should be stopped before 36 weeks of pregnancy.

How to take Duphaston

The dosage of Duphaston and the course of treatment are chosen individually by the doctor in accordance with the test data, the general picture and the patient's complaints. As a rule, when planning a pregnancy, the drug is started a few weeks before conception and continues up to the 16th week. If the level of hormones has decreased in the later stages of bearing a baby, treatment is continued until 24-25 weeks.

According to the instructions, the scheme for taking the tablets is as follows:

  • With the growth of the endometrium, take 1 tablet of Duphaston 2-3 times a day, constantly or from the last day of the menstrual cycle to day 25.
  • With a high level of estrogen hormones, but a low level of the hormone progesterone in the luteal phase, they drink 1 tablet of the drug from the moment of ovulation to the 25th day of the cycle. The recommended course of treatment is 6 months, and after conception - throughout the first trimester of pregnancy.
  • With the threat of miscarriage, spontaneous abortion or other pathologies, 4 tablets are prescribed for the first time, then 1 piece 3 times a day until the problem is eliminated.
  • To prevent or eliminate uterine bleeding, doctors recommend taking 1 tablet 2 times a day for 7 days.

Missed medication

You need to drink tablets regularly, without missing a single day. If during the treatment of certain problems you accidentally forgot to take Duphaston, according to the instructions, you need to drink the prescribed dose of the drug within the next 6 hours. If more time has passed since taking the recommended dose, then you should not drink an additional pill, you need to continue treatment according to the prescribed scheme.

How to cancel Duphaston during pregnancy

Cancellation of hormonal therapy should be gradual and only on the recommendation of the attending physician, when the level of progesterone, according to the laboratory, returned to normal. A sharp rejection of any hormonal medication can lead to side effects and cause irreversible reactions in the body. Duphaston should be canceled during pregnancy according to the following scheme:

  • If a woman has previously taken 2 tablets per knock, then the dosage of the drug should be reduced to 1.5 tablets.
  • A week later, the same dosage should be reduced to 1 tablet and so on until the drug is completely abandoned.

special instructions

The combined use of the drug with drugs containing estrogen hormones should be administered with caution to patients with renal insufficiency, heart or vascular disease, epilepsy, diabetes or chronic headaches. The active components of Duphaston do not affect the speed of thinking and reaction. When undergoing hormonal therapy, you need to regularly undergo a mammogram examination.

Interaction with drugs

Throughout treatment, and especially at the beginning of pregnancy, you should not combine Duphaston for pregnant women with broad-spectrum antibiotics, hypnotics or antiepileptic drugs, such as Rifampicin or Phenobarbital. Otherwise, Duphaston may not have the desired effect. Cases of incompatibility of this medicinal product with other medicines are unknown.

Side effects and overdose

Pregnancy against the background of Duphaston, as a rule, proceeds without consequences for the mother and child. However, in rare cases, there may be side effects which are easily eliminated by dosage adjustment. Among the negative reactions there are such cases:

  • When using too small doses, spotting from the uterus may appear.
  • Sometimes there is soreness of the chest, discomfort in the epigastric region and the appearance of headaches.
  • Very rarely, skin rashes, accumulation of fluid - swelling of the limbs and other allergic reactions are possible.
  • For some women, when taking hormonal drugs decreased or increased sexual desire.
  • Cases of overdose with Duphaston during pregnancy have not been identified.

Contraindications

Dufaston and pregnancy are two inseparable concepts. However, with caution, the drug is prescribed if in the anamnesis of a pregnant woman there were violations in the liver - jaundice, severe pruritus. The second most important indicator for drug withdrawal is the tendency to allergic reactions to one or more substances from the composition. The drug is stopped if the pregnancy is frozen, bleeding of unknown origin occurs, or ectopic pregnancy. It is strictly forbidden to take pills in the presence of:

  • Rotor or Dubin-Jones disease;
  • severe liver disease;
  • malignant neoplasms of the mammary glands or genital organs;
  • severe thrombophlebitis or a tendency to thrombosis.

Terms of sale and storage

In pharmacies, Dufaston is released upon presentation of a prescription from a gynecologist. It is necessary to store tablets at a temperature from 0 to 30 degrees Celsius in a place protected from sunlight and children. Do not take Duphaston after the expiry date which is stated on cardboard box. Under all conditions, the maximum shelf life is 5 years.

Duphaston's analogs

Synonymous drugs should not only differ from Duphaston in price, but also have similar properties and principles of influence on the body of a pregnant woman. At the same time, some medicines may have a distinctive composition, which is a plus for those who suffer from individual intolerance to dydrogesterone or other substances. At the risk of miscarriage or violations in the formation of the placenta, the doctor may prescribe one of the following Duphaston analogues:

  • Dufaston;
  • Dydrogesterone;
  • Utrozhestan;
  • Progesterone;
  • lutein;
  • Injesta.

Duphaston price

You can buy the drug at any pharmacy reasonable price or order home delivery of medicines from the online store. Upon receipt of the goods, you must provide the seller with the original prescription from the doctor. How much Dufaston costs in Moscow pharmacies is indicated in the table:

Many women who have made the decision to become a mother face the problem of conceiving and bearing a child. The reason for this may be chronic diseases of the internal genital organs, as well as adverse environmental factors. Many women are interested in the question of why Duphaston is prescribed during pregnancy for early dates. In modern medicine, there are well-established methods for using the drug Duphaston, which contributes to the onset and maintenance of pregnancy.

If a woman decides to use the drug, then she needs to agree on the dosage regimen and dosage with her doctor. The clinical effect of Duphaston on pregnancy has been experimentally proven.

The drug is available in tablet form. The composition of the drug includes components similar in their action to the hormone progesterone. This drug is well tolerated by the female body, without causing side effects. The basis of the action of the drug is the normalization of the activity of the mucous membrane of the uterine cavity (endometrium).

The onset of pregnancy after Duphaston occurs as soon as possible. Unlike its analogues, this drug does not have a depressant effect on nervous system without causing drowsiness and apathy.

Spontaneous abortions most often occur due to increased tone of the smooth muscles of the uterus. The drug Duphaston during pregnancy is prescribed to women in order to relax the uterine muscles. Most often, the drug is recommended in early pregnancy.

Preservation of pregnancy when taking Duphaston is observed in 85% of cases. If a woman has a tendency to increased uterine tone, gynecologists prescribe this remedy even before the baby is conceived.

The main indication for prescribing the drug is insufficient production of the hormone progesterone in the female body. Before starting a substance, a woman must receive laboratory confirmation of a progesterone deficiency.

In the early stages

The main indications for the use of Duphaston in early pregnancy include:

  • high risk of spontaneous abortion;
  • endometriosis;
  • dishormonal bleeding;
  • habitual miscarriage.

At a later date

The standard instruction for the use of Duphaston during late pregnancy recommends taking the substance with an increase in the tone of the uterine muscles, resulting in a risk. In this case, we are talking about birth.

The drug is highly effective in relation to infertility caused by hormonal disorders in the body of a woman.

In the vast majority of cases, the drug is favorably tolerated by the woman's body, and pregnancy against the background of Duphaston proceeds favorably. The main contraindication for taking the drug in the early and late periods is the presence of individual hypersensitivity to the components of the drug. Care must be taken in inflammatory diseases of the liver (hepatosis).

Caution is recommended for those women who have previously had cases of an allergic reaction. It is strictly forbidden to combine the drug with alcohol, since the effect of ethyl alcohol on the liver prevents the neutralization of the decay products of Duphaston.

Often, women may experience discharge when taking Duphaston during pregnancy, which are natural in nature.

Instructions for use

In order to get the expected result, it is important to know how to drink Duphaston during pregnancy on different terms. The official instructions for the use of the drug involves the use of the drug inside. With the growth of the mucous layer of the uterus (endometriosis), the optimal dosage of the drug is 1 tablet 3 times a day from 5 to 25 days of the menstrual cycle.

If a woman has a risk of spontaneous abortion, the dosage of Duphaston during pregnancy is 4 tablets at a time, after which it is recommended to continue taking the medication 1 tablet every 8 hours, until the alarming symptoms disappear.

Taking Duphaston in the first trimester of pregnancy is most justified. Taking Duphaston with brown discharge during pregnancy will help to avoid bleeding at different times. Colored discharge after Duphaston during pregnancy is a variant of the norm.

With a high risk of premature fetal rejection, a woman is recommended to get advice on how to take Duphaston during pregnancy with such a pathology. The optimal dose of Duphaston during pregnancy is 1 tablet 2 times a day, up to the 20th week of pregnancy.

If a woman is diagnosed with hormonal infertility, the amount of the substance taken is 1 tablet 1 time per day from the 14th to the 25th day of the cycle. The duration of treatment with Duphaston for infertility is at least six months.

For pregnancy, Duphaston and Proginova can be used in combination.

With painful menstruation, it is recommended to use 1 tablet of the substance 2 times a day from the 11th to the 25th day of the cycle. In case of menstrual irregularities and hormonal instability, it is necessary to take 1 tablet 2 times a day from the 5th to the 25th day of the menstrual cycle.

If a woman suffers from amenorrhea, then the essence of drug therapy is the combined use of Duphaston and medications containing estrogens. With amenorrhea, the dosage of the substance is 1 tablet 2 times a day from the 11th to the 25th day of the cycle.

To stop uterine bleeding, a dosage of 1 tablet 2 times a day for 7 days is used.

The attending physician will tell you how much to drink Duphaston during pregnancy.

Distribution and excretion from the body

The absorption of Duphaston tablets during pregnancy into the blood occurs in the intestinal cavity. The maximum content of the active ingredient in the blood plasma is fixed after 1.5-2 hours from the moment of taking the medication. Duphaston is distributed throughout the woman's body through contact with albumin. The chemical transformation of the components of the drug is carried out in the liver tissue, under the action of special enzymes.

The drug is excreted from the body through the urinary system. The duration of the half-life is from 17 to 19 hours. The period of complete elimination takes up to 70 hours. In the absence of renal pathology, there were no problems with the excretion of the substance from the woman's body.

How long is the drug used?

In the first trimester of pregnancy, the body of the expectant mother experiences the greatest need for progesterone. In most cases, the use of Duphaston during pregnancy is justified up to 20 weeks, since it further use loses all meaning. The use of funds in the early stages has its own principles:

  • it is strictly forbidden to independently replace the drug with its analogues;
  • taking the drug is carried out according to the medical scheme;
  • If you experience anxiety symptoms, it is recommended to contact your doctor immediately.

You can check with your doctor for how long to take Duphaston during pregnancy.

How to cancel Duphaston?

Proper drug withdrawal is a sensitive issue that must be approached gradually. The standard tactic is to gradually reduce the dosage by 1/2 tablet of the drug every 7 days. This will avoid sudden changes in hormonal levels and pregnancy failure.

If a pregnant woman takes 2 tablets per day, then she needs to reduce the daily dosage to 1.5 tablets. After another week, the dosage is 1 tablet per day. Thus, the dose of the drug is reduced to zero.

The attending physician will tell you how much to take Duphaston during pregnancy and how to cancel it correctly. It may take several weeks to completely stop the drug.

Side effects

The drug Duphaston during pregnancy causes side effects in rare cases:

  • Adverse reactions from the immune system are manifested in the form of allergic reactions varying degrees gravity.
  • With the formation of adverse reactions from the digestive organs, the functional state of the liver is disturbed, which affects the levels of bilirubin in the blood.
  • The function of hematopoiesis is inhibited, as a result of which hemoglobin falls.
  • A negative reaction can be obtained from the organs of the reproductive system. The therapeutic dosage of the drug causes bleeding in some women, which is treatable with dose adjustment of the drug.

Speaking about how Duphaston affects pregnancy, we can conclude that the effect of this drug is multifaceted.

Since the start of the release of the drug in the practice of medical specialists, there have been no cases of negative reactions provoked by an overdose of the drug. That is why the question of whether Duphaston is harmful during pregnancy disappears by itself.

It is not recommended to combine taking Duphaston at the beginning of pregnancy and throughout it with drugs such as Phenobarbital and Rifampicin. Such experiments can lead to inhibition of the medicinal effect of the drug.

Taking the drug Duphaston to maintain pregnancy must first be agreed with the attending gynecologist. Before starting therapy with progesterone preparations, it is recommended to familiarize yourself with possible consequences. The process of hormone replacement therapy should take place under strict quality control of treatment.

The ingestion of the substance into the body does not cause disturbances in the organs of the urinary system. The active components of the drug do not affect the ability to perform precise work and drive a vehicle. The characteristic signs of pregnancy on Duphaston do not differ from the standard symptoms.

Before starting the use of the drug, it is necessary to pay attention to the selection of a therapeutic dosage. This issue is dealt with by a medical specialist.

Useful video with expert advice on taking progesterone during pregnancy

Today it is extremely difficult to find a woman who, directly during her own pregnancy or during the period when she was just planning one, would not use any medicines that are useful for the expectant mother herself and completely safe for her unborn baby. After all, on the one hand, such foresight gives a woman an excellent opportunity to give birth to her long-awaited baby quite healthy. On the other hand, it allows you to maintain your own health. AT recent times such a diagnosis as habitual miscarriage is becoming a very common problem for women who really want to have their own children. The reasons for this are truly unusually many, but one of the most important of these reasons is the problems that a woman has on hormonal level her body.

As many already know, a strictly special hormone is “responsible” for the entire pregnancy, it is also called the pregnancy hormone - this is progesterone. As a rule, its main function is indispensable in the female body, which is preparing for possible cardinal changes - namely, to bear a baby. After all, firstly, progesterone usually helps the fetal egg to attach to the walls of the uterus in a timely and reliable manner, and it is he who prepares the female mammary glands for further production of both colostrum and milk. And secondly, thanks to just such a hormone as progesterone, the uterus is constantly growing quite actively and increasing in size, while practically not shrinking at all, which, of course, is extremely necessary precisely in order to female body was able to accept an embryo that he perceives as a "foreign body", and did not reject it.

And as you understand, as soon as another pregnancy occurs, the total amount of progesterone in the body increases dramatically. But, unfortunately, this, alas, does not always happen, because we described a variant of the accepted norm. There are a number of specific reasons why the very necessary pregnancy hormone for a woman may not be produced in sufficient quantities. And it’s quite understandable that without such a hormone, the uterus that penetrates into it may simply not accept the fetus (a spontaneous miscarriage will occur), and sometimes pregnancy may simply not occur at all.

And we tell you about all this, not in vain. Probably, you yourself have already guessed that in this article we will further discuss such a drug as the so-called synthetic analogue of this very necessary female progesterone for pregnancy. As a rule, this drug is prescribed only when it has been accurately confirmed in a particular woman (naturally, only after passing all the necessary tests for the production of hormones by the body). By the way, it would be desirable to donate blood for the hormones produced by the body several times. better in a row(this is necessary in order to determine as accurately as possible with your particular hormonal picture), and always strictly on an empty stomach. The results of such analyzes will have to be deciphered only by your attending physician, and then he may consider it necessary to prescribe you some additional studies. And only after that the doctor will allow himself to prescribe certain medicines for a particular woman.

Why is Duphaston usually prescribed?

Yes, first of all, because our modern pharmaceutical market is able to offer us only two similar drugs from real-life progesterone analogues - this is the same Duphaston and the second drug called. Such a drug as Duphaston, although it is still the same progesterone of only synthetic origin, nevertheless it is more convenient for a woman to use it, at least unlike the same Utrozhestan. After all, Utrozhestan is progesterone, but already of natural origin, which doctors should only administer strictly intramuscularly. And as mentioned earlier, (let's say with such a diagnosis as habitual non-carrying of a pregnancy), so actually during a pregnancy that has already begun, but which has real risks of interrupting it. Also, the drug Utrozhestan is also prescribed when planning a pregnancy - read more about this.

The correct dosage, and indeed the full course of treatment, should always be developed strictly individually, and depending on the available test results. Most often, they try to prescribe Duphaston in a dosage of 2 or a maximum of 3 tablets once or even twice a day. The full course of treatment with this drug is usually up to 6 months directly during the planning and preparation for pregnancy, and already with the onset of pregnancy, Duphaston should be taken only in the very first weeks of pregnancy, moreover, according to the same instructions, but constantly gradually reducing the intake the number of tablets, up to the complete abolition of those.

Also, such a drug as Duphaston may well be prescribed if it occurs, which most often happens in the early stages of pregnancy due to acute progesterone deficiency. And, as a rule, in this case, this drug is taken only up to 20 weeks of pregnancy, until the placenta can finally form in the woman’s body (after all, it has long been known that the already “ready” or ripe placenta significantly increases the production of the body itself, which is natural progesterone , and as a result, the fetus becomes protected from rejection by the mother's body).

Incredibly many questions in previously ill women can be caused by the process of canceling a drug such as Duphaston against the background of pregnancy. And, of course, on numerous forums, future and already established mothers actively share their experience, which, by the way, is very, very different. Many of the women Duphaston was canceled literally immediately at the first sign of pregnancy, but, unfortunately, the abrupt cancellation of this particular drug can be very dangerous for the fetus. After all, Duphaston supports a newly pregnant body with an additional, so necessary dose of the pregnancy hormone progesterone, and if suddenly such a supply of hormones is stopped too abruptly, then the woman’s uterus will be able to reject the fetal egg itself as a foreign body. And that is why a drug like Dufaston will need to be canceled only gradually, moreover, from time to time it will be necessary to take tests for the production of hormones in order to strictly control the total amount of progesterone in the female body.

How exactly can Duphaston be canceled?

Unfortunately, in this question, as well as in many others, there is no clear and unambiguous answer among physicians. And the same reviews of "experienced" mothers are very different from each other. But modern doctors on this occasion can be unambiguous in only one thing. Namely, that the regimen for the abolition of Duphaston will have to be determined only by an experienced doctor, who, in fact, initially prescribed the regimen for taking the drug. After all, it is shown that Duphaston happens to women for completely different reasons, which is precisely why, and this drug will need to be canceled accordingly.

If you, for example, took this drug, exactly 4 tablets a day, and subsequently the results of the relevant tests showed that the total amount of progesterone is now normal, then this drug may be canceled as follows. On the first day you will have to drink - the prescribed four tablets, on the second day we drink - only 3 tablets, on the third day - 2 tablets, respectively, on the fourth day - you guessed it 1 tablet, and only after that is it possible to completely stop taking such a drug as Duphaston. If the total amount of progesterone in the woman's body is somewhat deviated from the existing norms, then, of course, you will need a completely different scheme for drug withdrawal, which the doctor will have to determine, based on the indicators of deviations from the norm, which he saw in the tests. Sometimes pregnant women "stop taking" Duphaston on their own, and sometimes they do this for even a few weeks, which is also not entirely true.

And finally, let's talk about the so-called "pitfalls" possible when taking and canceling Duphaston. So, in the instructions for this drug (and actually from the lips of the vast majority of the most experienced and respected gynecologists) it is written in black and white that this drug can be absolutely safe, and can not harm either the expectant mother or, of course, her child. Rather, on the contrary, this drug is only very useful and even vital for almost every woman. However, it should be noted that some experts are extremely outraged by such information in the manufacturer's instructions. Indeed, in our days, and so Duphaston and the onset of pregnancy have become almost synonymous with words. And such a fairly serious drug is prescribed, as they say right and left, and sometimes without any serious reason, rather, just in case, calming oneself - because it will not hurt. But is it really so - the big question?

It is incredibly difficult to talk about this, so we bring to your attention only some of the statements of quite authoritative experts. It turns out, but in many civilized countries of the world, taking such a drug as Duphaston during pregnancy is considered to be extremely undesirable and even harmful. No matter how you twist it, and whatever you say, it is hormonal and means a rather serious drug that may well upset your natural hormonal balance in the body in some way. And some of the experts generally believe that such a reception of Duphaston can “slow down” the normal natural production of progesterone by an already pregnant body. Actually, that is why if you have already taken this drug before pregnancy, then during the onset of pregnancy, it is absolutely impossible to abruptly cancel it, of course. Since your already pregnant body may not be able to independently cope with the need to produce such an important and even vital hormone, for the simple reason that the body has already been “accustomed” to receiving this hormone from the outside. And if in the early stages of pregnancy the level of progesterone in your body drops sharply, then it will be extremely difficult for you to avoid a spontaneous miscarriage.

And in order not to face such a dilemma (do I need to cancel Duphaston during pregnancy or not, and if so, how?), It would be necessary to never take it at all. The last of modern studies have shown and proved that in fact, only a few women can really need such an “artificially derived” progesterone, and almost every second of all pregnant women is prescribed this drug.

Such an "ambiguous" attitude to drugs in our time is, unfortunately, quite a common thing. And how truly difficult it is for a pregnant woman to do in such a situation right choice when the information constantly coming to her is so contradictory and confusing. What should you do if, for example, one doctor insists that it is necessary and important to use this drug, and the second convinces that it is definitely not worth it?

The final choice, unfortunately, as always, falls only on the fragile shoulders of a pregnant woman ... and so much I want not to be mistaken in this matter.

Believe in your own strength, listen to your body and everything will be fine with you, of course!

Often, today, many women who want to become mothers face problems conceiving and bearing a baby, such problems can be identified among 16-20% of women who seek help from a doctor.

Today, there are schemes developed by gynecologists that involve taking duphaston, a drug that helps in the onset and maintenance of pregnancy.

Why is Duphaston prescribed during pregnancy

Duphaston is a medical preparation for oral administration in tablets. It has progestogenic activity against the uterine mucosa (it is an analogue of natural progesterone).

This drug is well perceived by the woman's body, without affecting the health of the liver, while it normalizes the state of the endometrium of the uterus, without disturbing the process of menstruation and ovulation.

This increases the chances of successful conception, reducing the risk of miscarriage and fading of pregnancy.

Duphaston, unlike its counterparts, does not have a sedative effect on the nervous system, does not affect the tone of the uterus, and does not have anabolic, estrogenic and corticoid effects. When taken, it almost does not cause side effects and increases the resistance of nerve tissues to damaging factors.

Taking Duphaston during pregnancy

Duphaston is usually prescribed in the early stages of pregnancy, or even from the planning stage of pregnancy and continues to be taken from the moment of conception.

The drug is prescribed by a gynecologist, and in most cases the drug is indicated in order to maintain and safely prolong the pregnancy until the time when the placenta takes over the functions of hormone synthesis.

By taking duphaston during pregnancy, the level of progesterone in the blood plasma is normalized, which contributes to normal course pregnancy.

Duphaston during pregnancy can also be used in case of a threat of termination, in order to prevent miscarriages during ICSI or IVF procedures, in case of previous abortions in the early stages or in the presence of a missed pregnancy in the anamnesis.

If the drug is used as prescribed by a doctor, the question of whether it is possible to drink duphaston during pregnancy does not even arise - it is directly indicated.

How does it affect pregnancy

With many years of research on the drug, the positive aspects of taking duphaston during pregnancy are confirmed.

The drug used in the planning phase prepares the uterus and its inner layer for conception, and then helps in the successful conception, implantation and development of the fetus until the placenta finally develops and it takes over the functions of producing hormones.

When using duphaston, a significant decrease in the percentage of spontaneous abortion in the first weeks of pregnancy was revealed, as well as the risks of fetal malformations and various anomalies in the development of the placenta.

An additional supply of progesterone can help the area of ​​​​the future placenta in creating hormonal, nutritional and oxygen balance for the fetus.

Due to this, children born while taking duphaston have normal weight, physical and psycho-emotional health at birth.

Is Duphaston dangerous during pregnancy?

Any drugs can become dangerous with uncontrolled use or self-medication, which is also true for duphaston.

Specialists with systemic and proper administration call difaston a harmless and absolutely safe drug during pregnancy.

According to the statistics of taking the drug, for a long time of its use in obstetrics and gynecology, there has not been a single case of a harmful and negative effect of duphaston on the processes of conception or gestation.

Moreover, sometimes without this drug, pregnancy will simply be at risk, and it is vital for the full development of the fetus in the first trimester.

Naturally, the drug should be taken under the supervision of a doctor and when determining the level of hormones in the woman's blood, with its further correct cancellation in time.

Duphaston is taken orally, and when absorbed into the blood, it has a selective effect on the endometrium of the uterus, which helps to prevent its excessive growth or the degeneration of endometrial cells into malignant ones with an excess of estrogens in the body.

Duphaston has no contraceptive effects, it is unable to inhibit ovulation and disrupt menstrual functions, but it helps a lot during pregnancy.

The drug is very well and quickly absorbed from the intestine into the blood, reaching a maximum concentration in the blood in about two to three hours. The drug is metabolized in the liver, without harming its functions, and excreted by the kidneys for two days.

This allows you to maintain its stable concentration in the blood at the desired level throughout the course of treatment.

How to take Duphaston during pregnancy?

The doctor will develop the correct regimen for taking the drug, based on the problem that interferes with the normal onset or course of pregnancy.

If this is an overgrowth of endometrial tissue, it is usually prescribed in a tablet two to three times a day, from the last day of menstruation to the 25th day of the cycle, or continuous administration of the drug.

If this is a failure of the second phase of the cycle (luteal), the drug is prescribed from the day of ovulation to the 25th day of the cycle. Usually, in order to prepare for a successful pregnancy, the reception is carried out up to six months in a row, and when a successful conception occurs, it is also continuous throughout the first trimester of pregnancy.

If duphaston is used with the threat of spontaneous miscarriage, 4 tablets are usually prescribed immediately, and then one three times a day until the threat stops.

How to drink duphaston during pregnancy - the doctor will write for you if it was prescribed before pregnancy, it is mandatory to take it up to 16 weeks of pregnancy.

The exact dose is determined by the doctor, based on the degree of threat and the level of progesterone in the blood of the pregnant woman.

If progesterone was not used before pregnancy, or there was a sharp decrease during pregnancy, the appointment of duphaston can be continued until 24-25 weeks of pregnancy at the discretion of the doctor.

The exact duration of treatment will be determined by the doctor, based on the results of the examination and examinations, your well-being.

The drug is usually used in the first trimester so that the fetus is successfully implanted and the placenta is formed.

But according to the indications, it is possible to use duphaston during the second trimester to prevent miscarriage, and sometimes the third. But after 36 weeks of pregnancy, the drug is always canceled.

If the drug is missed - what to do?

Of course, it is better not to skip taking the drug, but given its cumulative effects, this is not critical.

If one tablet is missed (forgotten, it was not possible), it is recommended to drink the next dose in the next 6 hours.

If more than six hours have passed, no additional dose is required, continue taking the drug as usual.

Try not to miss taking the drug, adhering to the same time. This will maintain optimal high concentrations of the substance in the blood plasma.

Cancellation of duphaston during pregnancy

The drug is canceled gradually, and the doctor will tell you how to reduce the dose of duphaston during pregnancy.

Usually, a gradual decrease in dosage of 0.5 tablets per week is carried out so that there is no sharp jump in hormonal levels and pregnancy failure.

For example, when taking two tablets per day, the dose is reduced to 1.5 tablets, and then a week later to one. Gradually reduce the dose to nothing.

Duphaston: side effects during pregnancy

Side effects as a result of taking duphaston are rare, and are usually easily corrected by changing the dose of the drug.

When taking the drug in small doses, there may be daubing and slight bleeding, which are eliminated when the dose is increased. The sensitivity of the mammary glands may increase, headaches or epigastric pains occur.

Rare may be skin rashes, swelling in the legs or arms, changing sexual desire (decrease or increase). In general, this is extremely rare, and the drug is well tolerated.

An overdose of the drug has not been reported in the literature so far.

Can Duphaston terminate a pregnancy?

Duphaston is a synthetic analog of the corpus luteum hormone of pregnancy, it does not have contraceptive and abortive effects. It does not apply to the means of abortion.

It is designed, on the contrary, to help maintain pregnancy, and cope with the threats of its termination.

Contraindications for admission

The main contraindication to taking it is individual intolerance to the drug and allergic reactions to its intake.

Also, the drug is not prescribed for rare Rotor and Dubin-Jones syndromes, severe liver damage, malignant tumors of the breast and reproductive organs.

Very carefully prescribe the drug for thrombophlebitis and a tendency to thrombosis.

Other related information


  • Are pregnancy and antibiotics compatible?

  • Folic acid is essential from conception

Many women in anticipation of a baby are faced with the problem of bearing. Bloody discharge can appear at any time, but competent treatment started on time will help maintain the pregnancy without disturbing the normal development of the fetus. "Dufaston" during pregnancy acts as an analogue of the "gestation" hormone. What are the indications for its use? And which is better and safer to use - "Dufaston" or "Utrozhestan"?

"Dufaston" is a synthetic analogue of women's own hormone - progesterone. The latter is secreted after ovulation, is responsible for normal growth and endometrial development, and supports embryonic development up to 22 weeks and beyond. The lack of this hormone in the body provokes not only a violation of the menstrual cycle, but also the appearance of a threat of miscarriage and even miscarriages. The competent appointment of "Duphaston" in many cases helps to cope with such problems.

Is it really necessary to take it

The attitude to the appointment of "Duphaston" before and already during pregnancy is ambiguous. This is due to the lack of a reliable evidence base on its effectiveness, as well as different tactics for managing pregnant women in Europe and Russia. But it can be reliably said that there is still an excessive and in many cases unnecessary prescription of the drug. This can be explained as follows.

  • Faith of the patient in a miracle drug. Many women and even doctors are confident in the "miraculous" Duphaston. In order to avoid another misunderstanding between the patient and the doctor, the latter enters the maximum possible into the appointments.
  • Low qualification of individual specialists. There are many reasons for the threat of miscarriage. But progesterone deficiency is detected in no more than 10% of cases, when its appointment is required.
  • Difficulty diagnosing progesterone levels. For many hormones, it is difficult to “catch” the right moment to take an analysis and then determine their amount in the blood. In order for the result on progesterone to show the true picture, blood should be taken on the 10th day after ovulation or already during pregnancy. Not every institution, especially a public hospital or clinic, can afford such a definition.

Thus, the question of why Duphaston is prescribed during pregnancy often remains open. The only argument that is given in most cases: "For safety net." Is this medicine safe? In many European countries, Duphaston is used only after detecting a low level of progesterone in a woman's blood. And often pregnancies up to three months are not kept at all, considering them obviously unsuccessful and defective.

Main Effects

After the onset of ovulation, the corpus luteum (remnants of the burst follicle) begin to produce progesterone. It is necessary for the following processes in the body of a woman.

  • Preparing the uterus for conception. It is needed for normal changes in the endometrium, which prepare it for implantation (implantation) of the fetal egg.
  • Preservation of pregnancy. The hormone reduces the intensity of uterine muscle contractions, which reduces the risk of miscarriage for a period of two to three weeks and thereafter.
  • Protection of the fetal egg. Progesterone increases mucus secretion from the fallopian tubes. It is necessary in the first few days for the fetal egg as a source of nutrition and for its normal movement to the uterine cavity.
  • Fetal development support. Progesterone is necessary for the normal development of the embryo in the first three months. Over time, the placenta itself begins to synthesize this hormone and the corpus luteum gradually fades.

With a lack of progesterone production by the corpus luteum and later by the placenta, various violations of the growth and development of the embryo are observed. But if you correct the deficiency with Duphaston in time, the likelihood of maintaining a pregnancy increases significantly. Thus, the role of progesterone in a woman's body is great, especially during pregnancy.

"Dufaston" during pregnancy: indications

"Dufaston", as a synthetic analogue of progesterone, is prescribed in cases where a deficiency of the hormone's own production is expected. Most often, pregnancy on Duphaston passes in women with the following indications.

  • With an initial decrease in progesterone levels. "Dufaston" is prescribed even during the planning period to all women with a detected deficiency of endogenous (own) progesterone according to the results of the tests. This allows you to increase the chances of a successful conception.
  • With the threat of spontaneous miscarriage. "Dufaston" is used for spotting in a pregnant woman, as well as in the presence of signs of detachment according to the results ultrasound uterus.
  • If you have a history of miscarriages. To correct the endocrine background before and after conception, synthetic progesterone is often prescribed.
  • If conception occurred as a result of IVF. In vitro fertilization protocols involve the creation of artificial cycles to increase the likelihood of successful conception and subsequent growth of the embryo. Therefore, after IVF, an additional hormonal support progesterones.

You should not start taking the drug on your own. Despite its relative safety, taking incorrect doses without indications can aggravate rather than improve the situation. How to take "Dufaston" during pregnancy in each case can only be said by a gynecologist after examination and examination.

Admission schemes

Pregnant women are always interested in the question of how long to take Duphaston and in what dosage. Reception regimens depend on the clinical situation, the presence of complaints from the pregnant woman, as well as the results of laboratory tests.

  • During planning. To correct the second phase of the cycle, the drug is prescribed 10 mg twice a day, starting from 12-14 days and ending with days 25-26. If conception has occurred on Duphaston, the medicine is not canceled in the future, but its maintenance dose (20 mg / day) is kept for up to 12-16 weeks.
  • With the threat of miscarriage. If spotting or other signs of detachment of the ovum are present, it is necessary to drink four tablets (40 mg) of the drug once, and then one every eight hours. At a dose of 30-40 mg / day, you can take Duphaston for a week, gradually reducing the dose when the symptoms of a threatened miscarriage disappear. Further, it is recommended to take a maintenance dose (20 mg / day) for at least two to three weeks.
  • With habitual miscarriage. "Dufaston" is recommended for prophylactic use at a dose of 20 mg / day. When signs of a threatened miscarriage appear, the dose is increased.
  • After IVF. The dose of progesterone after the use of assisted reproductive technologies should be much higher than during a natural pregnancy, and it is prescribed individually. Usually it is even a combination of "Duphaston" and "Utrozhestan" in vaginal form. The total dose at the same time is several times higher than that used in normal pregnancy.

You can drink the drug both before and after meals, but it is better to take it in several doses, and not in one dose. The main thing is to observe an equal time interval (every 8 or 12 hours). It is allowed to take "Duphaston" up to 32 weeks inclusive, but if there is no need for it, you should immediately cancel the remedy.

The benefits of the drug

"Dufaston" has a number of properties that distinguish it from other progestins. He:

  • does not have other hormonal effects;
  • does not lead to the appearance of signs of the opposite sex in the fetus;
  • does not affect thermogenesis, so you can easily determine the basal temperature;
  • after two hours reaches maximum concentrations in the blood;
  • does not tend to accumulate in the body;
  • completely removed within three days.

When not to use

There are practically no contraindications to the use of the drug. It should not be taken if you have a history of allergic reactions to progesterone. Caution should be taken when taking medication for violations of the liver, especially with some hereditary syndromes.

Adverse reactions

"Dufaston" during early pregnancy can help lower blood pressure and cause dizziness and nausea in a woman. If the effect is strongly pronounced, it is recommended to switch to the use of its analogues, for example, Utrozhestan.

The following side effects from taking the pills are also possible:

  • discomfort in the chest;
  • skin rash;
  • headache;
  • depressive states.

The frequency of their occurrence is extremely small, given the reviews of practicing gynecologists and instructions for using the drug.

Which is better: "Utrozhestan" or "Dufaston"

"Dufaston" has several analog drugs. The most common is "Utrozhestan". It belongs to the category of natural gestagens, therefore it is unreasonably considered by some experts to be more effective and useful.

But "Utrozhestan" has one clear advantage - it has a form of vaginal tablets. So you can reduce the transformation of synthetic progesterone in the body and increase the effectiveness of the drug.

It is believed that "Dufaston" is more suitable for spotting and signs of detachment, and "Utrozhestan" with an increase in the overall tone of the uterus, shortening of the cervix and to prevent premature birth. But based on why Duphaston is usually prescribed during pregnancy, there is no fundamental difference between it and Utrozhestan.

Is the hormone safe?

Most researchers argue that Duphaston is one of the most effective and safe drugs. But its appointment should be treated with caution. This is due to the fact that its long-term effect on adolescent children, especially girls, has not yet been studied. There are opinions that the use of "Duphaston" without indications further affects the reproductive system of girls, leading to polycystosis, anovulation and other problems.

Thus, "Duphaston" is an artificial analogue of progesterone, which is used in obstetrics and gynecology to correct the hormonal background of a woman. The drug is so popular and shrouded in "miraculous" myths that sometimes it is not even clear why Duphaston is prescribed during pregnancy in some women. There are no specific data on the safety and effectiveness of the drug, so you should always use it with caution, weighing all the pros and cons.

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